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Literature summary for 3.4.21.122 extracted from
- Combined analysis of TMPRSS2-ERG and TERT for improved prognosis of biochemical recurrence in prostate cancer (2012), Genes Chromosomes Cancer, 51, 781-791 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | TMPRSS2-ERG is the most common gene fusion in prostate cancer. 74% (117/158) of the prostate adenocarcinomas analyzed were positive for the TMPRSS2-ERG and/or telomerase TERT expression. Significantly higher expression of ERG is detected in TMPRSS2-ERG-positive tumors, whereas more intense expression of SPINK1 is characteristic for the TMPRSS2-ERG negative tumors. The cases negative for both transcripts, TMPRSS2-ERG and TERT, rarely recurr and show significantly longer biochemical recurrence-free period as compared to the TMPRSS2-ERG and/or TERT-positive cases | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O15393 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| prostate cancer cell line | - |
Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
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Release 2023.1 (January 2023)
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